Much of the fundamental research in computer science has been driven by the needs of those attempting to utilize computing for various applications, such as health and medicine. Dr. Patel will describe a collection of research projects conducted with his clinical collaborators that leverage the sensors on mobile devices and wearables (e.g., microphones, cameras, accelerometers, etc) in new ways to enable the screening, self-management and longitudinal study of diseases. Much of the innovation in this work look relies on the co-design of new sensing and AI techniques. These projects follow the theme of finding unique signals and biomarkers in order to enable access and scale by leveraging existing hardware. His remarks will underscore the potential advances in health and clinical science through the convergence of sensing, machine learning/AI, and human-computer interaction.