Avram Hershko

Avram Hershko (2010) - Roles of Protein Degradation in Health and Disease (Lecture + Discussion)

The selective degradation of many short–lived proteins in eukaryotic cells is carried out by the ubiquitin-mediated proteolytic system. In this pathway, proteins are targeted for degradation by covalent ligation to ubiquitin, a highly conserved small protein