In 1962 Hamilton Smith gets a Postdoctoral Fellowship at the Human Genetics Department at the University of Michigan, Ann Arbor.

Hamilton Smith and his family move to Champaign-Urbana, Illinois in 1937. He and his brother receive private French lessons and piano lessons. Smith completes High School in three years and so graduates at the University Laboratory High School in Urbana in 1948.

Hamilton Smith and J. Craig Venter sequence the first bacterial genome, that of Haemophilus influenza at the Institute for Genomic Research in 1995.

Hamilton Smith joins the J. Craig Venter Institute, where he´s currently leader of the synthetic biology and biological energy groups.

Hamilton Smith enters John Hopkins University Medical School in Baltimore, where he gains his Medical Doctor's degree in 1956.

Hamilton Smith meets the nursing student Elizabeth Anne Bolton at the Barnes Hospital and a few months later they get married. They have four sons and one daughter.

Hamilton Smith works together with geneticist Myron Levine, who studies Salmonella Phage P22 lysogeny. Both demonstrate the sequential action of the P22 C-genes which controlled lysogenization. They discover the gene controlling prophage attachment, the int gen in 1965.

Hamilton Smith does a medical internship at Barnes Hospital in St Louis, before he serves in the Navy for two years (1957-1959). During his Navy time he has spends most of his time with reading textbooks on genetics. After that he moves to Detroit, where he works at the Henry Ford Hospital. There he deals with the genetics of bacteriophages.

Hamilton Othanel Smith is born as the youngest of two sons to his parents Bunnie Othanel, a University Professor and the teacher Tommie Naomi Harkey in New York City, United States.

First entering the University of Illinois in 1948 Hamilton Smith transfers to the University of California, Berkeley in 1950. There he receives his Bachelor's degree in Mathematics in 1952.

Hamilton Smith discovers the first Type II restriction enzyme, now called HindII and determines the sequence of its cleavage site.

Hamilton Smith shares the 1978 Nobel Prize for Medicine or Physiology with Daniel Nathans and Werner Arber for the discovery of restriction enzymes and their application to problems of molecular genetics.

Hamilton Smith continues working on the human genome at the new founded Celera Genomics Corporation.

From 1975 to 1976 Hamilton Smith gets a Guggenheim Fellowship , which he spends at the University of Zürich.

In 1967 Hamilton Smith is appointed Assistant Professor of Microbiology at the John Hopkins University, in 1973 he becomes Full Professor and remaining at John Hopkins University he becomes Professor of Molecular Biology and Genetics in 1981.