Paul Hermann Müller is born in Olten, Switzerland.

In the following year, he joins Lonza A.G. as an assistant chemist in the Scientific-Industrial Laboratory of their electrical plant, gaining a wealth of practical knowledge which later turns out useful in his career as an industrial chemist. 

He begins his career at the Laboratory of the J.R. Geigy Dye-Factory Co. in Basel. First he does research on vegetable dyes and tanning agents. He also works on disinfectants, on moth-proofing agents for textiles, and on pesticides in general. He synthesizes dichlorodiphenyltrichloroethane (DDT). DDT had already been made in 1873 by an Austrian student, but now Müller discovers its effectiveness against many kinds of insects.

He commences work in 1916 as a laboratory assistant at Dreyfus and Company. 

He marries Friedel Rüegsegger in 1927. They have two sons and one daughter.

The family moves to Basel where Paul attends primary school and later Free Evangelical elementary and secondary schools. He matriculates in 1918 and returns to obtain his diploma in 1919.

He studies at Basel University under Professors Fichter and Rupe for his Doctorate which he receives in 1925.

Paul Müller dies in Basel, Switzerland.