Jerome Karle enters the Chemistry Department of the University of Michigan. Here, he takes his degree with Professor Lawrence O. Brockway whose specialty is the investigation of gas-phase molecular structure by means of electron diffraction.

Jerome Karle marries Isabella Lugoski, a classmate, who was sitting at an adjoining desk during his first course in physical chemistry.

Jerome Karle enters the City College of New York. Here, Karle finds a concentration of the best students in New York City. He follows courses that range through mathematics, the physical sciences, the social sciences and literature. In addition to the requirements (which include also two years of compulsory public speaking courses), he studies some mathematics, some physics, and much chemistry and biology.

Karle and Hauptman publish a monograph, The Phases and Magnitudes of the Structure Factors, in which they demonstrate how phase structures can be inferred directly from diffraction patterns. By 1954, Karle and Hauptman lay the foundation for the direct method of X-ray crystallography (a technique in which the pattern produced by the diffraction of X-rays through the closely spaced lattice of atoms in a crystal is recorded and then analysed to reveal the nature of that lattice).

Jerome Karle accepts a position in Albany, New York with the New York State Department of Health, with the intention to accumulate enough money to pay for further graduate studies. Here, he develops a method to measure dissolved fluorine levels, a technique that will become a standard for water fluoridation.

Although his Ph.D. degree is awarded in 1944, Jerome Karle has completed all the work for it during the summer of 1943. Therefore, he decides to leave the University of Michigan for a while to work on the Manhattan Project at the University of Chicago. His wife Isabella joins him on this project a few months later.

Jerome Karle attends Abraham Lincoln High School in Brooklyn. The standards of education of this school are very high. When he has the opportunity, Karle enjoys handball, ice skating, touch football and swimming in the nearby Atlantic Ocean.

Jerome Karle receives the Nobel Prize in Chemistry jointly with Herbert A. Hauptman "for their outstanding achievements in the development of direct methods for the determination of crystal structures, a technique that is used to study the biological, chemical, metallurgical and physical characteristics."

Jerome Karle is born in New York City. He grows up in a Jewish family with strong artistic tendencies. His mother, a skilled pianist, dreams for him of a future as a professional musician, but Karle foresees for himself science as a lifelong career.

Jerome Karle goes with his wife to work permanently in Washington for the Naval Research Laboratory. They continue their researchers in developing the quantitative aspects of gas electron diffraction analysis. While in Washington, Karle begins an important collaboration with Herb Hauptman exploring new ways to determine the structure of crystals using X-ray diffraction techniques. He retires on 31 July 2009.

Jerome Karle returns to the University of Michigan and accepts to work on a project of the Naval Research Laboratory. There, he performs some experiments on the structure of monolayers of long-chain hydrocarbon films involved in the boundary lubrication of metallic surfaces. He also derives a theory that explains the electron diffraction patterns obtained from the oriented monolayers.

Jerome Karle dies of liver cancer at the Leewood Healthcare Center in Annandale, Virginia.

After his bachelor, Jerome Karle spends a year at Harvard University. Here, he receives his master's degree in biology.