In 1960, he becomes head of the Department of Physiology at University College London. Later in 1969, he is appointed to a Royal Society Research Professorship there. He is a fellow at Trinity College, Cambridge, until his death.

In 1947 Andrew Huxley marries Jocelyn Richenda Gammell Pease, who is a Justice of the Peace, and is active in a variety of public work in Cambridgeshire. They have six children.

He dies in Grantchester.

In August 1939, Huxley joins Alan Hodgkin at the Marine Biological Laboratory at Plymouth to study nerve impulses. They eventually discover the basis of the propagation of nerve impulses (called action potential), using the giant axon of the Atlantic squid. Their work later earns them the Nobel Prize.

Andrew Huxley shares the 1963 Nobel Prize in Physiology with Sir John Eccles and Alan L. Hodgkin, "for their discoveries concerning the ionic mechanisms involved in excitation and inhibition in the peripheral and central portions of the nerve cell membrane".

Andrew is educated at University College School.

After the war, he resumes research at Trinity College in Cambridge, where he develops interference microscopy. From 1946 to 1951, Huxley works with Alan Hodgkin on nerve conduction, and also with R. Stämfli on myelinated nerve fibres. In 1952, he is joined by the German physiologist Rolf Niedergerke. Together they discover in 1954 the mechanism of muscle contraction, popularly called the "sliding filament theory”, which is the foundation of modern understanding of muscle mechanics. 

He continues his education at Westminster School, turning from classics to science in 1932.

Andrew Fielding Huxley is born in Hampstead, London. His father was a son of the nineteenth-century scientist and writer Thomas Huxley.

He goes to Trinity College, Cambridge in 1935 with a scholarship, studying physics, chemistry and mathematics at first. Since the rules require him to take another science, he picks physiology. As it turns out, he finds physiology interesting, and he decides to specialise in it.

Soon after the outbreak of World War II, when medical teaching in London is stopped by air attacks, Huxley is recruited by the British Anti-Aircraft Command. He spends the war on operational research in gunnery, first for Anti-Aircraft Command and later for the Admiralty. From 1941 until 1946 he is research fellow at the Trinity College in Cambridge.