Avram Hershko receives the Israeli Prize for his contributions to Israeli society through biochemistry and medicine.

Avram Hershko becomes Professor at the Israel Institute of Technology (Technion), where he has taught since 1972.

Avram Hershko takes a sabbatical year, after six years at Technion. He spends it working with Irwin Rose, who he had met one year before, and wo is also interested in protein degradation. Rose is the third major influence in Hershko’s research, after Mager and Tomkins. For over twenty years, Hershko will continue the collaborate, visiting Rose often at the Fox Chase Cancer Centre in Philadelphia.

Avram Hershko meets Judith Leibowitz, a Swiss student doing a year abroad in the hematology laboratory in Jerusalem. The couple marries by the end of the year. They have three sons, Dan (1964), Yair (1968), and Oded (1975), and six grandchildren. Judith becomes an occasional researcher at Hershko’s Unit of Biochemistry around 1971.

Avram Hershko is born in Karcag, second son of Shoshana and Moshe Hershko, who are school teachers. As World War II begins, Moshe is taken by the Hungarian Army for forced labor at the Russian front. He is then captured by the Soviets, also for forced labor, and is only reunited with his family in 1946. Shoshana is taken out of Hungary with her sons and parents-in-law in 1944. They are boarded on a train to Auschwitz, but, by luck and an anonymous bribe, the train heads to Austria instead.

Avram Hershko, now 13 years old, emigrates with his family to Israel, after living in Budapest for three years. In Jerusalem, once the language barrier is overcome, Moshe Hershko resumes his teaching. The two children are sent to a private school, despite the relative poverty of the family. Avram will follow his brother in the study of medicine “by default”, since his interests span over a large scope disciplines.

Avram Hershko receives the Weizmann Prize for Sciences.

Avram Hershko returns to Israel and is offered a chair of biochemistry in a new medical school in Haifa (Technion), and “temporarily” (for 15 years…) housed in an old monastery. The Unit of Biochemistry is very small due to the lack of space. Here, Hershko does much of the discovery of the ubiquitin system. For years, his team tries in vain to establish a cell-free system that reproduces energy-dependent protein degradation in the test tube, essential for the biochemical analysis of this system.

Avram Hershko carries on with his research on how proteins are degraded only with a biochemically analyzable cell-free system. At first, and for a long time, his team has no successful results. Eventually, they use the reticulocyte cell-free system established in the Goldberg laboratory for biochemical fractionation. At this time, Aaron Ciechanover joins the Unit as a graduate student

Avram Hershko works as a postdoctoral fellow with Gordon Tomkins, at the Department of Biochemistry and Biophysics of the University of California, San Francisco. Here, Hershko learns about protein degradation.

Avram Hershko starts working at Jacob Mager’s laboratory. At the time, the university did not offer a formal PhD program, but it offered the possibility of one year of research before the clinical years of the medical program. Hershko completes his medical studies, but decides he wants to do research instead. With Mager, Hershko works in a board range of subjects within biochemistry.

Avram Hershko interrupts his studies to do his military service as a physician.

Avram Hershko receives the Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation. The prize is shared with his old student Aaron Ciechanover and with his close friend Irwin Rose.

Avram Hershko receives the Lasker Award for Basic Medical Research, with A. Ciechanover and A. Varshavsky.

Avram Hershko starts his studies at the Hebrew University - Hadassah Medical School in Jerusalem, where he falls in love with biochemistry, which he learns in three different courses: organic chemistry, taught by Yeshayahu Leibowitz; basic biochemistry, by Shlomo Hestrin; and physiological chemistry, by Ernst Wertheimer and Jacob Mager. Avram Hershko decides to ask the latter for permission to do research at his laboratory.

Avram Hershko returns to Mager’s laboratory to finish a PhD thesis.