Akira Suzuki (2013) - Cross-Coupling Reactions of Organoboranes: An Easy Way for Carbon-Carbon Bonding

Akira Suzuki (2013)

Cross-Coupling Reactions of Organoboranes: An Easy Way for Carbon-Carbon Bonding

Akira Suzuki (2013)

Cross-Coupling Reactions of Organoboranes: An Easy Way for Carbon-Carbon Bonding

Abstract

The palladium-catalyzed cross-coupling reaction between different types of organoboron compounds and various organic halides in the presence of base provides a powerful and general methodology for the formation of carbon-carbon bonds. The (sp3)C-B compounds (alkylboron compounds) and (sp2)C-B compounds (such as aryl- and 1-alkenylboron derivatives) readily cross-couple with organic electrophiles to give coupled products selectively in high yields. Recently, the (sp)C-B compounds (1-alkynylboron derivatives) have been also observed to react with organic electrophiles to produce expected cross-coupled products. Such coupling reactions offer several advantages:

As one of defects of the reaction, one would point out the use of bases. However, we could overcome the difficulty by using suitable solvent systems and adequate bases. Consequently, these coupling reactions have been actively utilized not only in academic laboratories but also in industrial processes.

In this lecture, the overview of the coupling reaction will be discussed.

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