Robert Huber (2007) - Proteolysis and its Regulation, a Molecular Basis

Robert Huber (2007)

Proteolysis and its Regulation, a Molecular Basis

Robert Huber (2007)

Proteolysis and its Regulation, a Molecular Basis

Abstract

Proteolytic enzymes catalyse a very simple chemical reaction, the hydrolytic cleavage of a peptide bond. Nevertheless they constitute a most diverse and numerous lineages of proteins. The reason lies in their role as components of many regulatory physiological cascades in all organisms. To serve this purpose and to avoid unwanted destructive action proteolytic activity must be strictly controlled. Control is based on different mechanisms which I will discuss and illustrate with examples of systems and structures determined in my laboratory.

a) by specific inhibition with natural and synthetic inhibitors
b) by enzymatic specificity
c) by activation from inactive precursors accompanied or not by allosteric changes
d) by co-localization of enzyme and substrate
e) by cofactor binding accompanied or not by allosteric changes
f) by controlled substrate processing and access to the proteolytic site


The regulatory principles offer new opportunities of intervention for therapeutic purposes and in crop science.

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