Irwin Rose becomes a Senior Member of the Fox Chase Cancer Center in Philadelphia where he stays until retiring in 1995 and where he conducts his Nobel Prize winning research.
Irwin Rose accepts a position as Distinguished Professor-in-residence in the Department of Physiology and Biophysics at the UC Irvine College of Medicine in California.
Irwin Rose is invited by Joseph Fruton to become an Instructor in Biochemistry at Yale University Medical School. His interest in protein breakdown starts when he learns about the ATP requirement for it in a liver slice system. His main interest from now on will be studying the mechanism of enzyme action.
Irwin Rose attends Lewis and Clark High School in Spokane.
Irwin Rose enters Washington State College. Here he is strongly influenced by Prof. Herbert Eastlick, who stimulates his students to set high standards for themselves. Rose serves in the U.S. Navy as a radio technician near the end of World War II.
Irwin Rose's family relocates in Spokane, Washington, due to the health problems of Irwin's brother, who is advised to go to a high and dry climate. The father remains in Brooklyn to tend his flooring business and he visits the rest of the family in Spokane from time to time.
Irwin Rose receives one third of the Nobel Prize in Chemistry along with Aaron Ciechanover and Avram Hershko "for the discovery of ubiquitin-mediated protein degradation". Some illnesses are caused by failures or malfunctions in the protein-degradation system, and a better understanding of this phenomenon has led to the development of better drugs to combat cancer, cystic fibrosis, Alzheimer’s and Parkinson’s diseases.
Rose earns his Ph.D. at the University of Chicago. For his thesis he tries to determine if the DNA content of rat tissues increases if there is B12 in the diet. He analyses the DNA of tissues of rats fed with diets that varied in B12. The project fails as the genetic nature of DNA is revealed, and he finds that the DNA content per cell of liver is independent of diet. He chooses then a new project: looking at the construction of DNA from various base components using carbon-14 labelled compounds.
Ciechanover and Hershko work with Rose discovering a process by which cells degrade, or destroy, the proteins that no longer serve any useful purpose. A molecule called ubiquitin attaches to the protein targeted for destruction and accompanies it to a proteasome that divides the protein into amino acids. The outer membrane of the proteasome admits only proteins carrying an ubiquitin molecule. Ubiquitin detaches before entering the proteasome. Cells reuse it to tag other proteins for destruction.
Irwin Rose accepts a post-doc position at New York University with Severo Ochoa.
Irwin Rose attends public school, P.S. 134. In these years he develops a passion for handball.
Irwin Rose accepts a post-doc position at Western Reserve University with C. E. Carter.
Irwin Rose is born in Brooklyn, New York, into a secular Jewish family, the son of Harry Royze and Ella Greenwald, who own a flooring store.
Irwin Rose earns his Bachelor in Biochemistry at the University of Chicago.