Edwin Krebs attends Urbana High School, an excellent institution with dedicated teachers and a variety of extracurricular activities. Here he completes the last three years of high school.
Hans Krebs is forced to leave Nazi Germany for England. There he continues his research at the University of Cambridge with a Rockefeller Studentship until 1934, when he is appointed Demonstrator of Biochemistry in the University of Cambridge.
Hans Krebs earns his Ph.D. at the University of Hamburg.
Edwin Krebs and Ed Fischer discover that a protein kinase moves a phosphate group from adenosine triphosphate (ATP) to a protein. The shape and the function of the protein are altered. When the role of the protein is completed, a protein phosphatase removes the phosphate and the protein returns to its original state. This biochemical process of reversible protein phosphorylation regulates the activities of proteins in cells and thus governs countless processes essential for life.
Edwin Krebs takes eighteen months of residency training in internal medicine at Barnes Hospital.
Hans Krebs is appointed Whitley Professor of biochemistry in the University of Oxford, and the Medical Research Council's research unit is transferred there. He is also elected a Fellow of Trinity College, Oxford.
Hans Krebs fulfils his required year of hospital service at the Third Medical Clinic. In his spare time he undertakes a study of the gold sol reaction. With Annalise Wittgenstein he begins concurrently experiments on dogs on the passage of foreign substance from the blood into the cerebrospinal fluid. Krebs decides to employ dyes whose presence in the cerebrospinal fluid could easily be detected colorimetrically. He designs the experimental approach and writes the papers reporting the results.
Hans Krebs attends the Gymnasium Andreanum in Hildesheim. At the age of fifteen, Krebs decides that he wants to follow his father into medicine.
Hans Krebs moves to Freiburg to become an assistant to Siegfried Thannhauser, an expert on metabolic diseases in the Department of Medicine. He spends much of his time on clinical duties at the same time, during his first three months, he continues his investigation of carbohydrate metabolism, but in July he begins a new project: he wants to determine how urea is synthesized in the animal organism.
After the sudden death of the father in 1933, Krebs's mother decides to move the family to Urbana, where two of her sons are already enrolled at the University of Illinois.
Edwin Krebs is founding Chairman of the Department of Biological Chemistry at the University of California.
Hans Krebs moves on to the University of Munich because of the general renown of its clinical faculty. He stays here for two semesters. He returns to Munich for the summer semester of 1923, and in the fall of that year passes, with very good marks, the final medical examination (Ärztliche Prüfung).
Edwin Krebs marries Virginia Deedy French, a student nurse at Washington University.
Edwin Krebs enters Washington University School of Medicine. He takes several laboratory projects, first under Dean P. A. Schafer, and later under Arda A. Green. Ethel Ronzoni also helps him in some of the work. During this period he hears for the first time about the enzyme phosphorylase, which is found to exist in two interconvertible forms (phosphorylase b and phosphorylase a).
Edwin Krebs receives half of the Nobel Prize in Physiology or Medicine along with Edmond H. Fischer "for their discoveries concerning reversible protein phosphorylation as a biological regulatory mechanism".
Hans Krebs finds a position with heavy clinical responsibilities at the municipal hospital of Altona, near Hamburg, in the Department of Medicine, directed by Leo Lichtwitz, an outstanding physician with an interest in metabolic diseases. In order to obtain Warburg’s support for a grant to purchase materials to do research, he is obliged to undertake an investigation of proteolysis in tumour cells for Warburg.
Hans Krebs receives one half of the Nobel Prize in Physiology or Medicine "for his discovery of the citric acid cycle".
Hans Krebs discovers (together with the German biochemist Kurt Henseleit) a series of chemical reactions (now known as the urea cycle) by which ammonia is converted to urea in mammalian tissue; the urea, far less toxic than ammonia, is subsequently excreted in the urine of most mammals. This cycle also serves as a major source of the amino acid arginine.
Krebs enters the University of Illinois. He takes biology to meet premedical requirements but also math, chemistry, and physics. He wins a scholarship to attend medical school; therefore he decides finally to become a physician, instead of getting a Ph.D. in organic chemistry. He carries out research in organic chemistry under H. Snyder and C. Price. He is inspired also by C. S. Marvel. Due to this introduction to research, he becomes a research biochemist rather than a clinician.
Edwin Krebs is born in Lansing, Iowa, the third of the four children of William Carl Krebs, a Presbyterian minister and his wife, Louise Helen Stegeman, a teacher. During Krebs's youth, his family relocates several times. The first destination is Newton.
Hans Krebs moves to the University of Freiburg. In the anatomical institute Wilhelm von Möllendorff, a leader in the field of vital staining, invites him to study comparatively the staining effects of different dyes on muscle tissue. Krebs finds that the intensity and distribution of the staining in muscle tissue are ruled not by the respective chemical properties of the dyes but by the degree of their dispersibility and the varying densities of the tissue structures.
Hans Krebs dies in Oxford at the age of 81.
Hans Krebs is allowed to enter as a veteran midway through the school term and for that reason he works very hard to learn what he had missed.
At the age of 6 Edwin Krebs moves with his family to Greenville, Illinois. He develops various interests such hiking, sand-lot sports, fishing, stamp collecting, and ham radio. He loves also reading, especially historical novels about the Civil War and the settling of the West. He shows his growing interest in science producing gun powder and maintaining a balanced aquarium.
Warburg finds that carbon monoxide inhibits the respiration of yeast cells, but that illuminating the cells diminishes the extent of the inhibition. In 1928 Krebs finds a heme-pyridine compound with responses to carbon monoxide and to HCN so similar to the responses of yeast cells that Warburg can regard the compound as a model of the respiratory enzyme that he had postulated before. He uses Krebs’s results to strengthen his argument that the respiratory enzyme itself is an iron-heme compound.
Krebs finds a cycle of chemical reactions that combines the end-product of sugar breakdown with the four-carbon oxaloacetic acid to form citric acid. The cycle regenerates oxaloacetic acid through a series of intermediate compounds while liberating carbon dioxide and electrons, immediately used to form high-energy phosphate bonds in the form of adenosine triphosphate. This discovery is fundamental to a basic understanding of cell metabolism and molecular biology.
Hans Krebs is appointed Lecturer in Pharmacology at the University of Sheffield, and in 1938 Lecturer-in-Charge of the Department of Biochemistry newly founded there. His appointment is upgraded to a professorship, and he is also director of a research unit of the Medical Research Council already established in his department.
Hans Krebs is drafted into the army. He is assigned to a signal corps regiment in Hannover where he completes only a few weeks of basic training. Returning home, Krebs is able to obtain an immediate discharge on the grounds that he intends to enrol as a medical student at the nearby University of Göttingen.
Edwin Krebs returns to the University of Washington as Chairman of the Department of Pharmacology. At the UW he is also appointed Investigator in the Howard Hughes Medical Institute. He becomes then Professor Emeritus in the Department of Biochemistry. For decades after his retirement as Professor Emeritus, he walks regularly from his home to his UW lab to conduct researches and meet students.
Krebs publishes a short paper that marks his emergence as an independent investigator and his entry in the field of intermediary carbohydrate metabolism. Starting from the recent discovery by Einar Lundsgaard that muscles poisoned with iodoacetate could continue to contract for a short time even though they could not produce lactic acid, and extending Lundsgaard’s results to other animal tissues, Krebs shows that lactic acid added to slices poisoned with iodoacetate restores their respiration.
Edwin Krebs joins the University of Washington in Seattle as Assistant Professor of biochemistry. In 1953 Ed Fischer joins the department. Shortly, Krebs and Fischer starts working together on the enzymology of phosphorylase. They are able to observe the mechanism by which interconversion of the two forms of phosphorylase takes place: reversible protein phosphorylation.
Edwin Krebs goes on active duty as a medical office in the navy.
Edwin Krebs's Professor of medicine, Dr. W. B. Wood, suggests him to study in a basic science department. Krebs is accepted by Dr. Carl and Gerty Cori as a Postdoctoral Fellow. In their laboratory he studies the interaction of protamine with rabbit muscle phosphorylase, and he falls in love with biochemistry.
Hans Krebs enrols in a special chemistry course offered at the Charité Hospital for doctors who need to strengthen their chemical backgrounds. There he spends most of 1925 learning to carry out basic methods of qualitative and quantitative analysis.
Hans Krebs is born in Hildesheim to Georg Krebs, an ear-nose-throat surgeon and his wife Alma, née Davidson. His father instils in him interest in nature, in particular in wildflowers. Krebs is shy and quite introverted but also diligent, organized, and an avid reader. He has hobbies such as botanical collecting and bookbinding. He also studies piano. Although his parents come from Jewish families, Hans and his brother are raised outside the formal faith.
Edwin Krebs dies in Seattle for heart failure at the age of 91.
Hans Krebs becomes a paid research assistant to the biochemist Otto Warburg at the Kaiser-Wilhelm Institut für Biologie. He learns the tissue slice and manometric methods that Warburg had devised in order to measure the rates of respiration and glycolysis of cancer cells and to compare these with the rates in normal tissues. Krebs extends the measurements that Warburg had made on rat tumour tissue to tissues obtained from human patients.
Hans Krebs spends the winter semester in Berlin to hear lectures by some of the leaders in medicine.