Brian Josephson attends Cardiff High School, where the physics master M. S. Jones introduces him to theoretical physics.

Brian Josephson becomes a research student in the university's Mond Laboratory, Cambridge, UK. He is supervised by Brian Pippard and follows some lectures of Philip W. Anderson who introduces the new concept of broken symmetry in superconductors. He is elected a fellow of Trinity College in 1962, and obtains his M.A. and PhD in 1964 for a thesis entitled "Non-linear conduction in superconductors," which contains the discovery that will gain him the Nobel Prize.

Extending earlier works in tunnelling done by Leo Esaki and Ivar Giaever, at the age of 22, Brian Josephson predicts theoretically the phenomenon of superconducting now called Josephson effect. The effect describes a current that flows indefinitely long without any voltage applied across a device known as a Josephson junction, which consists of two superconductors coupled by a weak link. In 1963, Anderson and J. Rowell verify the Josephson effect at the Bell Labs.

Brian Josephson is born in Cardiff, Wales, to Jewish parents, Mimi (née Weisbard) and Abraham Josephson.

In 1974, Brian Josephson becomes full Professor of Physics at the University of Cambridge, UK. He holds this position till his retirement in 2007.

In 1957, Brian Josephson goes to Cambridge to study mathematics at Trinity College. After completing Maths Part II in two years he decides to switch to physics and receives his B. A. in 1960. While still an undergraduate, he publishes an important paper on the Mossbauer effect.

In 1967, Brian Josephson returns to Cambridge as assistant director of research at the Cavendish Laboratory, where he is a member of the Theory of Condensed Matter group.

Brian Josephson is National Science Foundation Senior Foreign Scientist Fellow at Cornell University.

Brian Josephson becomes Reader in Physics at the University of Cambridge.

Brian Josephson is Visiting Professor at the Computer Science Department, Wayne State University, Detroit, USA.

In 1987, Brian Josephson is Visiting Professor at the University of Missouri-Rolla.

After retiring, Brian Josephson continues to work at the Cavendish Laboratory as the director of the Mind-Matter Unification Project of the Theory of Condensed Matter Group - a project created by Josephson in 1996 with the aim to understand "from the viewpoint of the theoretical physicist, what may loosely be characterised as intelligent processes in nature, associated with brain function or with some other natural process."

Brian Josephson moves to the United States to take a position as research assistant professor at the University of Illinois at Urbana-Champaign.

Brian Josephson receives the 1973 Nobel Prize in Physics "for his theoretical predictions of the properties of a supercurrent through a tunnel barrier, in particular those phenomena which are generally known as the Josephson effects." Josephson shares the prize with Leo Esaki and Ivar Giaever "for their experimental discoveries regarding tunnelling phenomena in semiconductors and superconductors, respectively."

In the late 1960s, Brian Josephson becomes interested in the Mind-Body problem, arguing that some parapsychological phenomena may be real. In the mid-1970s, Josephson becomes involved with a group of physicists associated with the Lawrence Berkeley Laboratory at the University of California, Berkeley, who are investigating paranormal claims. In 1976, Josephson travels to California to meet two leading members of the group, laser physicists Russell Targ and Harold Puthoff.

In 1984, Brian Josephson is Visiting Professor at the Indian Institute of Science, Bangalore, India.