Following the advice of his father Bruce Beutler spends two years in residency and internship at the UT Southwestern Medical Center. After this time he is convinced of a career in research.

Bruce Alan Beutler is born to Brondelle May Fleischer and Ernest Beutler in 1957 in Chicago, as one of four children. The Family soon relocates to Los Angeles, where his father works as a Department Chairman at the City of Hope Medical Center.

After struggling for years the gene Bruce Beutler and his team were looking for is discovered. TLR4 is essential for LPS signalling and the fact that LPS receptors are part of a protein family opened a window into how mammals perceive microbes and how TLRs signal initiate inflammatory responses.

Bruce Beutler moves his laboratory to the Scripps research Institute In La Jolla, as a professor in the department of immunology, eager to dissectinnate immunity in mammals. In 2007 he becomes chairman of The department of genetics.

Bruce Beutler attends Polytechnic School, a college preparatory school in Pasadena. He is fascinated by living things, raising many animals and early reading about molecular biology. During high school and college he is working in his father´s laboratory.

Looking for a laboratory of his own, Bruce Beutler is invited by Joe Sambrook to join Howard Hughes Medical Institute at UT Southwestern Medical Center. He focuses his work on the regulation of the biosynthesis of tumor necrosis Factors (TNF) and later on the Positional cloning of the LPS locus.

Bruce Beutler attends the University of Chicago, only 19 years old. He receives his M.D. In 1981.

During the summer of 1976 Bruce Beutler works in the laboratory of Abraham Braude and is introduced to Lipopolysaccharid (LPS) for the first time but he is only interested casually.

Bruce Beutler enrolls at the University of California at San Diego, in Revelle College to study medicine, strongly encouraged by his father. He graduates in 1976.

Bruce Beutler joins the Cerami Laboratory at the Rockefeller University, NY. He works on cachectin, isolating one of the key endogenous factors mediating the lethal effect of LPS. In 1985 he is promoted to the rank of an assistant Professor.

At 02:30am Bruce Beutler lays sleepless in his bed in a small apartment in San Diego. He checks his phone to see if there are any new messages - there is only one. He opens it and reads that he is awarded the Nobel Prize in Physiology or Medicine in 2011 together with Jules Hoffmann and Ralph Steinman for their discoveries concerning the activation of innate immunity. The ceremony takes place in Stockholm, on the 10th of December.

Bruce Beutler marries Barbara Lanzl, the marriage ends in 1988. They have three children.

In 2011 Beutler returns to the UT Southwestern Medical Center to Become director of the new centre for the genetics of host defense, in Which faculty with a forward genetic orientation working with diverse Model organisms.